You can quickly delete all instances of a title in Edelweiss using the Catalog ISBN Nuke Titles feature.
To get there, click into your Publisher page. There, if you have Catalog Administration privileges, you’ll see this if you make sure to click into the Administrative View:
Click that Nuke button to get to a screen that allows you to add one or multiple ISBN’s to delete, from either the US or All Markets.
Once Nuked, it will take about a day for the title to be fully ‘expunged’ from the system.